What is a D-Dimer test primarily used for?

The D-Dimer test is primarily used as a diagnostic tool for identifying blood clots, particularly in conditions such as deep vein thrombosis (DVT) and pulmonary embolism (PE). D-Dimer is a fibrin degradation product that is present in the blood after a blood clot dissolves. When the body forms and breaks down clots, it releases this substance into the bloodstream. Elevated levels of D-Dimer indicate increased clotting activity in the body, which can suggest the presence of significant clotting disorders.

In a clinical setting, when a patient presents with symptoms such as leg swelling or chest pain, the D-Dimer test can assist healthcare professionals in determining whether further imaging studies, like ultrasound or CT scans, are warranted to visualize any potential clots. While elevated D-Dimer levels are not exclusive to clotting disorders and can be influenced by various factors such as inflammation or recent surgery, a negative D-Dimer result can effectively rule out the presence of a significant thrombus in patients with a low probability of clot-related conditions.