Which of the following is a symptom of larynx cancer?

Persistent hoarseness is a significant symptom of larynx cancer due to the tumor affecting the vocal cords and surrounding structures in the larynx. When cancer develops in this area, it can disrupt normal vocal cord function, leading to changes in voice quality, including hoarseness that does not resolve over time. This symptom is particularly concerning if it lasts longer than two weeks and can prompt further investigation.

In contrast, the other options do not specifically relate to larynx cancer. Joint pain, severe fatigue, and skin rashes are more general symptoms that can arise from a variety of other medical conditions, including systemic illnesses or infections, rather than being directly indicative of laryngeal pathology. Focusing on the unique symptoms associated with larynx cancer is crucial for early detection and treatment.